Dr. Mario is main protagainist of the Dr. Mario series, but is also the doctor form of Mario, which instead of battling Bowser and saving Princess Peach, Dr. Mario and Nurse Peach battle germs. He appeared in Super Smash Bros. Melee and Super Smash Bros. For Nintendo 3DS and Wii U as an unlockable character. He is a stronger, yet slightly slower Mario.
- Dr. Mario (NES , Game Boy, 1990)
- Dr. Mario 64 (Nintendo 64 , 2001)
- Dr. Mario Online Rx (WiiWare , 2008)
- Dr. Mario Express (DSi , 2009)
- Dr. Luigi (Wii U, 2013)
- Super Smash Bros. Melee (Gamecube, 2001)
- Super Smash Bros. For Nintendo 3DS and Wii U (Nintendo 3DS/Nintendo Wii U, 2014)